Nanofibres in Drug Delivery
Gareth R. Williams (Author), Bahijja T. Raimi-Abraham (Author), C. J. Luo (Author)
In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory.
The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibres can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.
1 Introduction 1.1 Preamble 1.2 Nanofibres 1.3 Key concepts in drug delivery 1.4 Nanofibre characterisation 1.5 An overview of contemporary pharmaceutical technology 1.6 Summary 1.7 References 1.8 Bibliography 2 Electrospinning fundamentals 2.1 Background 2.2 A brief history of electrospinning 2.3 EHD fundamentals 2.4 Understanding the electrospinning process 2.5 The parameters affecting electrospinning 2.6 The experimental set- up 2.7 Fibre properties 2.8 Characterisation 2.9 Summary 2.10 References 3 Monoaxial electrospinning 3.1 Introduction 3.2 Experimental considerations 3.3 Fibre properties 3.4 Some typical results 3.5 Fast- dissolving drug delivery systems 3.6 Extended- release systems 3.7 pH- controlled delivery 3.8 Pulsatile release 3.9 Multilayer materials 3.10 Thermoresponsive systems 3.11 Emulsion and suspension electrospinning 3.12 Tissue- engineering applications 3.13 Using fibres as sacrificial templates 3.14 Conclusions 3.15 References 4 Coaxial and multi- axial electrospinning 4.1 Introduction 4.2 Experimental considerations 4.3 Extended- release systems 4.4 Targeted drug delivery 4.5 Multifunctional materials 4.6 Other applications 4.7 Protein delivery systems 4.8 Cell electrospinning 4.9 Modified coaxial spinning 4.10 Triaxial and quad- axial systems 4.11 Conclusions 4.12 References 5 Side- by- side electrospinning 5.1 Introduction 5.2 Experimental considerations 5.3 Janus fibres in drug delivery 5.4 Conclusions 5.5 References 6 Alternative nanofibre fabrication approaches 6.1 Introduction 6.2 Alternating current (AC) electrospinning 6.3 Melt electrospinning 6.4 Centrifugal spinning 6.5 Solution blowing and melt blowing 6.6 Electroblowing 6.7 Pressurised gyration 6.8 Electrospraying 6.9 Microfluidic spinning 6.10 Fibre production on the move 6.11 Other techniques 6.12 Conclusions 6.13 References 7 Moving from the bench to the clinic 7.1 Introduction 7.2 Scale- up 7.3 Regulatory requirements and GMP manufacturing 7.4 Conclusions 7.5 References 8 Conclusions and outlook
DOI: 10.14324/111.9781787350182
Number of pages: 242
Number of illustrations: 72
Publication date: 17 September 2018
PDF ISBN: 9781787350182
EPUB ISBN: 9781787350199
Read Online ISBN: 9781787350212
Hardback ISBN: 9781787350229
Paperback ISBN: 9781787350236
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Nanofibres in Drug Delivery
In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory.
The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibres can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.
